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FREQUENCY AND CHARACTERISTICS OF DISEASE FLARES IN ANKYLOSING SPONDYLITIS.
- Source :
-
Romanian Journal of Rheumatology / Revista Romana de Reumatologie . 2010, Vol. 19 Issue 2, p118-122. 5p. 2 Charts. - Publication Year :
- 2010
-
Abstract
- Objective: To examine the characteristics and frequency of disease flares in a cohort of people with AS. Methods: A prospective data set from a randomized controlled trial (RCT) of a probiotic treatment/placebo was utilized to examine disease flares in 134 people with AS. Disease flares were defined as either minor/localized flares (pain/swelling localized to one area with fatigue and stiffness) or major/generalized flares (generalized pain, hot burning joints, muscle spasm, fever, sweating, extreme fatigue and stiffness). Results: One hundred and thirty-four people were followed up for 1216 person follow-up weeks and there were 71.4 flares per 100 person-weeks. Of these, 12 were major/generalized flares and 59.4 were minor/localized flares. People who experienced at least one major/generalized flare during the study period had worse disease during flare-free periods in terms of disease activity, impaired function, self-reported night pain and iritis compared with those who did not experience any major/generalized flares during the study. Major/generalized flares lasted for an average of 2.4 weeks (S.D. 2.7), and were preceded by and followed by a minor/localized flare in 92% (55/60) of cases. Conclusion: Seventy per cent of people with AS felt they had a flare in any given week. Those who experienced major/generalized flares appear to have more severe and active disease even during periods when not in flare, compared with those who do not experience major/generalized flares. These results have implications for the timing of assessments prior to starting anti-TNF therapy and suggest that the presence of major flares may be helpful in identifying patients with severe disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18430791
- Volume :
- 19
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Romanian Journal of Rheumatology / Revista Romana de Reumatologie
- Publication Type :
- Academic Journal
- Accession number :
- 53696588