Eosinophil Sequestration and Activation Are Associated with the Onset and Severity of Systemic Adverse Reactions following the Treatment of Onchocerciases with Ivermectin.

Analyzes the role of eosinophil activation and sequestration in the development and severity of adverse reactions after treatment of Onchocerca volvulus infection with ivermectin. Decline in eosinophil counts in ivermectin-treated groups; Increase in the circulating levels of interleukin-5 and eosinophil-derived neurotoxin; Slin microfilarial densities before and after treatment.