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Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2010, Vol. 20 Issue 20, p6129-6132. 4p. - Publication Year :
- 2010
-
Abstract
- Abstract: A series of azulene-based derivatives were synthesized as potent inhibitors for receptor tyrosine kinases such as FMS-like tyrosine kinase 3 (FLT-3). Systematic side chain modification of prototype 1a was carried out through SAR studies. Analogue 22 was identified from this series and found to be one of the most potent FLT-3 inhibitors, with good pharmaceutical properties, superior efficacy, and tolerability in a tumor xenograft model. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 20
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 53789753
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.08.025