Back to Search
Start Over
Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice
- Source :
-
Journal of Neuroimmunology . Oct2010, Vol. 227 Issue 1/2, p101-110. 10p. - Publication Year :
- 2010
-
Abstract
- Abstract: Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 227
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 53796745
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2010.06.020