Enantioselective Nickel-Catalyzed Reductive Coupling of Alkynes and Imines.

The nickel-catalyzed reductive coupling of alkynes and imines with Et2Zn as a reductant by using electron-rich phosphine ligands has been developed, affording various allylic amines with high yields and excellent chemoselectivities. Chiral induction was also achieved in this reductive coupling reaction when a nickel catalyst containing a chiral spiro phosphine ligand was used. [ABSTRACT FROM AUTHOR]