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Enantioselective Nickel-Catalyzed Reductive Coupling of Alkynes and Imines.
- Source :
-
Journal of the American Chemical Society . 8/18/2010, Vol. 132 Issue 32, p10955-10957. 3p. 3 Diagrams. - Publication Year :
- 2010
-
Abstract
- The nickel-catalyzed reductive coupling of alkynes and imines with Et2Zn as a reductant by using electron-rich phosphine ligands has been developed, affording various allylic amines with high yields and excellent chemoselectivities. Chiral induction was also achieved in this reductive coupling reaction when a nickel catalyst containing a chiral spiro phosphine ligand was used. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 132
- Issue :
- 32
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 53877148
- Full Text :
- https://doi.org/10.1021/ja104505t