The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells.

The article reports on the study regarding matriptase, a type-II transmembrane serine protease, its structural requirements on ectodomain release in polarized epithelial cells. The study uses monkey kidney, the cell line establishes a tight junctions used as a model of polarized epithelia. The study found that the pos-translational cleavage between Gly149 and Ser150 and the existence of catalytic domain are critical for the ectodomain release of matriptase in stable transfection experiments.