Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.

Shows that deficiency of ADAMTS13, a member of the ADAMTS family of zinc metalloproteinase genes, is the molecular mechanism responsible for thrombotic thrombocytopenic purpura (TTP). Role of the proteolysis of von Willebrande and/or other ADAMTS13 substrates in maintaining the balance between bleeding and clotting; Genetic mutations related to TTP.