Back to Search
Start Over
Tailored α-methylene-γ-butyrolactones and their effects on growth suppression in pancreatic carcinoma cells
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2010, Vol. 20 Issue 22, p6620-6623. 4p. - Publication Year :
- 2010
-
Abstract
- Abstract: A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) were synthesized via allylboration and screened against three human pancreatic cancer cell lines (Panc-1, MIA PaCa-2, and BxPC-3). This systematic study established a discernible relationship between the substitution pattern of AMGBL and their anti-proliferative activity. β,γ-diaryl-AMGBLs, particularly those with a trans-relationship exhibited higher potency than parthenolide and LC-1 against all three cell lines. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 20
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 54482644
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.09.022