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SP1 acts as a key factor, contributes to upregulation of ADAM23 expression under serum deprivation
- Source :
-
Biochemical & Biophysical Research Communications . Oct2010, Vol. 401 Issue 2, p306-312. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: ADAM23 modulates many cellular functions, alteration of expression causes a number of tumor types; however, the mechanisms controlling ADAM23 expression remain unknown. Here we have identified a SP1 binding site (−202/−190) that binds SP1 at the proximal promoter of human ADAM23 gene; furthermore, serum deprivation enhances open chromatin accessibility and help expose the SP1 binding site; finally, SP1 binding recruits RNA polymerase II, which in turn results in upregulation of endogenous ADAM23 expression. Therefore, the present study delineates the fundamental elements of a core promoter structure that will be helpful for future studies of the regulation of ADAM23 gene. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 401
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 54486045
- Full Text :
- https://doi.org/10.1016/j.bbrc.2010.09.058