Modification of biologically active amides and amines with fluorine-containing heterocycles 4. Trifluoromethyl-containing heterocyclic pyracetam derivatives.

one-pot method for the synthesis of trifluoromethyl-containing heterocyclic pyracetam derivatives has been suggested by the reaction of pyracetam, hexafluoroacetone, and 1,3-binucleophiles, viz., 3-aminocrotononitrile, 6-aminouracyls, 6-aminothiouracyl, N-benzyl-3-aminocyclohexenone, and 2-aminothiazoline. [ABSTRACT FROM AUTHOR]