Alteration of Sensory Neurons and Spinal Response to an Experimental Osteoarthritis Pain Model.

The article discusses a study which examined the biologic links between progressive cellular and structural alterations within knee joint components and the development of symptomatic chronic pain. The study also investigated the molecular basis of alterations in nociceptive pathways caused by osteoarthritis (OA)-induced pain. It utilized Sprague-Dawley rats as animal models of knee joint OA pain. Study authors found structural changes in peripheral knee joint components in relation to central compartment alterations.