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Bortezomib: a new player in pre- and post-transplant desensitization?
- Source :
-
Nephrology Dialysis Transplantation . Nov2010, Vol. 25 Issue 11, p3480-3489. 10p. - Publication Year :
- 2010
-
Abstract
- Several desensitization strategies have been investigated for the reversal of acute antibody-mediated rejection or for the removal of preformed anti-HLA antibodies, with the aim to promote access to renal transplantation. Today, their success appears limited or incomplete. Bortezomib, a selective inhibitor of the 26S proteasome, which is largely used in the treatment of multiple myeloma, could be a novel promising desensitizing agent. Its mechanism of action and preliminary clinical use in renal transplantation is reviewed here. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09310509
- Volume :
- 25
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Nephrology Dialysis Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 54655325
- Full Text :
- https://doi.org/10.1093/ndt/gfq502