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Signaling to the Nucleus by an L-type Calcium Channel--Calmodulin Complex Through the MAP Kinase....

Authors :
Dolmetsch, Ricardo E.
Pajvani, Urvi
Fife, Katherine
Spotts, James M.
Greenberg, Michael E.
Source :
Science. 10/12/2001, Vol. 294 Issue 5541, p333-339. 7p. 7 Color Photographs, 10 Diagrams, 10 Graphs.
Publication Year :
2001

Abstract

Reports the development of a functional knock-in technique in investigations of the features of L-type voltage-activated channels. Creation of mutant channels for pharmacological blockers; Selective signalling of L-type calcium channels to the nucleus.

Subjects

Subjects :
*CALCIUM channels
*CELL nuclei

Details

Language :
English
ISSN :
00368075
Volume :
294
Issue :
5541
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
5483106
Full Text :
https://doi.org/10.1126/science.1063395