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Effect of age and Helicobacter pylori infection on gastric acid secretion.

Authors :
Haruma, Ken
Kamada, Tomoari
Kawaguchi, Hiroyuki
Okamoto, Shiro
Yoshihara, Masaharu
Sumii, Koji
Inoue, Masaki
Kishimoto, Shinya
Kajiyama, Goro
Miyoshi, Akima
Source :
Journal of Gastroenterology & Hepatology. Mar2000, Vol. 15 Issue 3, p277-283. 7p. 4 Charts, 1 Graph.
Publication Year :
2000

Abstract

AbstractBackground: Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and H. pylori infection. Methods: The presence of H. pylori infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. Helicobacter pylori infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0–4. Results: Both basal and maximal acid output decreased with age in H. pylori-positive subjects, while they did not change with age in H. pylori-negative subjects. Gastric acid secretion decreased with the progression of FAG. An age-correlated decrease in gastric acid secretion in H. pylori-positive subjects depended on an increasing prevalence of FAG with age. Conclusions: In the population studied, advancing age had no influence on gastric acid secretion in H. pylori-negative subjects. Gastric acid secretion decreases with age in H. pylori-positive subjects because of the increasing prevalence of FAG with age. © 2000 Blackwell Science Asia Pty Ltd. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08159319
Volume :
15
Issue :
3
Database :
Academic Search Index
Journal :
Journal of Gastroenterology & Hepatology
Publication Type :
Academic Journal
Accession number :
5520723
Full Text :
https://doi.org/10.1046/j.1440-1746.2000.02131.x