Direct cyclization of ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids into fused pyrrolizinones

Authors :: Aiello, Francesca
Garofalo, Antonio
Grande, Fedora
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2010, Vol. 51 Issue 50, p6635-6636. 2p.
Publication Year :: 2010
Abstract: Abstract: A series of fused heterocyclic compounds based on a pyrrolizinone structure have been prepared from ortho-(1H-pyrrol-1-yl)aryl and heteroaryl carboxylic acids by intramolecular Friedel–Crafts acylation promoted by bis(trichloromethyl) carbonate, in generally good yield without using Lewis acid catalysts. [Copyright &y& Elsevier]

Subjects :: *RING formation (Chemistry)
*FRIEDEL-Crafts reaction
*PYRROLES
*CHEMICAL reactions
*CARBOXYLIC acids
*HETEROCYCLIC compounds
*CHEMICAL structure
*ACYLATION

Language :: English
ISSN :: 00404039
Volume :: 51
Issue :: 50
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 55210184
Full Text :: https://doi.org/10.1016/j.tetlet.2010.10.060

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