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Antipruritic activity of extracts of Humulus scandens, the combinations of bioactive flavonoids
- Source :
-
Fitoterapia . Dec2010, Vol. 81 Issue 8, p1073-1078. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: The antipruritic effects of the ethanol fractions of Humulus scandens on the 4-AP (4-aminopyridine)-induced and chloroquine-induced scratching in ICR mice were examined. The 40% ethanol fractions of H. scandens suppressed both the 4-AP- and chloroquine-induced scratching behavior, which significantly inhibited degranulation of rat peritoneal mast cell and antigen-stimulated histamine release. Further studies proved that the 40% ethanol fractions of H. scandens decreased the content of IL4 in serum of chloroquine-induced scratching ICR mice. The results suggest that the 40% ethanol fractions of H. scandens has antipruritic effects on both antihistamine-resistant and -sensitive pruritus. [Copyright &y& Elsevier]
- Subjects :
- *LABORATORY mice
*ANTIPRURITICS
*DERMATOLOGIC agents
*ANTI-inflammatory agents
*HUMULUS
*MEDICINAL plants
*ANTIHISTAMINES
*ITCHING
*ALTERNATIVE medicine
*ANALYSIS of variance
*ANIMAL experimentation
*BIOPHYSICS
*COMPARATIVE studies
*COMPUTER software
*FLAVONOIDS
*HIGH performance liquid chromatography
*MAST cells
*RESEARCH methodology
*MICE
*MICROSCOPY
*STATISTICS
*PLANT extracts
*DATA analysis
*PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 81
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 55210341
- Full Text :
- https://doi.org/10.1016/j.fitote.2010.07.003