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Variability of the S gene of hepatitis B virus in southeastern China.
- Source :
-
Archives of Virology . Dec2010, Vol. 155 Issue 12, p1951-1957. 7p. 3 Diagrams, 3 Charts. - Publication Year :
- 2010
-
Abstract
- In a study of 315 HBV specimens obtained from southern China, 240 (76.9%) were assigned to genotype B, 72 (22.9%) were genotype C, two (0.6%) were genotype A and one (0.3%) was genotype D. Statistical analysis revealed that variables such as age, gender, HBV vaccination rate, hepatitis anamnesis rate, anti-HBs and HBeAg prevalence and virus load were insignificant between genotype B ( n = 240) and genotype C cases ( n = 72) ( P > 0.05). However, the frequency of amino acid (aa) substitutions in the major hydrophilic region (MHR; aa 99-169) and the putative HLA class I-restricted cytotoxic T lymphocyte (CTL) epitope region of the S gene, as well as the overlapping polymerase/RT region (aa 32-212), were significantly higher in genotype C group than genotype B ( P < 0.001). These results suggest that the higher variability within genotype C carriers may account for the pathogenic potential. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03048608
- Volume :
- 155
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Archives of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 55215848
- Full Text :
- https://doi.org/10.1007/s00705-010-0786-x