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Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolides
- Source :
-
European Journal of Medicinal Chemistry . Dec2010, Vol. 45 Issue 12, p5943-5949. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: A series of C-12 pyrazolinyl spiro ketolide derivatives were designed and synthesized. The C-12 modifications involved replacing the natural C-12 methyl group in clarithromycin core with different pyrazolinyl spiros via chemical synthesis. Potential anti-bacterial activities against both erythromycin-susceptible and erythromycin-resistant bacteria were reported. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 45
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 55378755
- Full Text :
- https://doi.org/10.1016/j.ejmech.2010.09.060