Design of a novel class of biphenyl CETP inhibitors

Authors :: Lu, Zhijian
Napolitano, Joann B.
Theberge, Ashleigh
Ali, Amjad
Hammond, Milton L.
Tan, Eugene
Tong, Xinchun
Xu, Suoyu S.
Latham, Melanie J.
Peterson, Laurence B.
Anderson, Matt S.
Eveland, Suzanne S.
Guo, Qiu
Hyland, Sheryl A.
Milot, Denise P.
Chen, Ying
Sparrow, Carl P.
Wright, Samuel D.
Sinclair, Peter J.
Source :: Bioorganic & Medicinal Chemistry Letters. Dec2010, Vol. 20 Issue 24, p7469-7472. 4p.
Publication Year :: 2010
Abstract: Abstract: A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model. [ABSTRACT FROM AUTHOR]

Subjects :: *DRUG design
*BIPHENYL compounds
*DRUG synergism
*TRANSGENIC mice
*PHARMACEUTICAL chemistry
*ANIMAL models in research
*ENZYME inhibitors

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