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Catastrophic antiphospholipid syndrome: Updated diagnostic algorithms
- Source :
-
Autoimmunity Reviews . Dec2010, Vol. 10 Issue 2, p74-79. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: The catastrophic antiphospholipid syndrome (APS) is the most severe form of APS with acute multiple organ involvement and small vessel thrombosis. During the 13th International Congress on Antiphospholipid Antibodies (aPL) a “Catastrophic APS Task Force” was developed to discuss the challenges in the diagnosis and management of catastrophic APS. The purpose of this paper is to summarize the diagnostic challenges (false-positive/negative aPL results and overlap with other thrombotic microangiopathies) and propose updated diagnostic algorithms for catastrophic APS. Important steps of the diagnostic algorithms include: a) history of APS or persistent aPL-positivity; b) three or more organ new thrombosis developing in less than a week; c) biopsy diagnosis of microthrombosis; and d) other explanations for multiple organ thromboses and/or microthrombosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15689972
- Volume :
- 10
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Autoimmunity Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 55389181
- Full Text :
- https://doi.org/10.1016/j.autrev.2010.08.005