Exo/endoselectivity-control in Lewis-acid catalyzed tandem heterocyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuranElectronic supplementary information (ESI) available: Representative experimental procedure and characterization of reaction products. CCDC 784918–784921. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0cc02778b

A novel catalytic exo/endoselectivity-controllable tandem heterocyclization/formal [4+3] cycloaddition was developed, which provides rapid, efficient and stereoselective access to highly fused polyheterocycles from readily available 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran under mild conditions. [ABSTRACT FROM AUTHOR]