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Antibiotic Resistance of Conjunctiva and Nasopharynx Evaluation Study: A Prospective Study of Patients Undergoing Intravitreal Injections
- Source :
-
Ophthalmology . Dec2010, Vol. 117 Issue 12, p2372-2378. 7p. - Publication Year :
- 2010
-
Abstract
- Purpose: To determine the baseline antibiotic susceptibility patterns of conjunctival and nasopharyngeal flora isolated from patients undergoing intravitreal (IVT) injections for choroidal neovascularization (CNV). Design: Prospective, observational study. Participants: Forty-eight eyes of 24 patients undergoing unilateral IVT injections for CNV. Methods: Bilateral conjunctival and unilateral nasopharyngeal cultures on the treatment side were taken before application of any topical medications. Main Outcome Measures: Bacterial isolates were identified and tested for antibiotic susceptibility to 16 different antibiotics using the Kirby-Bauer disc diffusion technique. Results: A total of 57 bacterial isolates were obtained from the conjunctiva of 48 eyes. Coagulase-negative staphylococci (CNS) accounted for 37 of the 57 isolates (65%). The most common CNS organisms were Staphylococcus epidermidis and Staphylococcus lugdunensis accounting for 73% and 11% of CNS isolates, respectively. More than half of S. epidermidis isolates demonstrated some level of resistance to ofloxacin and levofloxacin, and 33% and 37% of isolates showed some level of resistance against gatifloxacin and moxifloxacin, respectively. Some 60% and 30% of CNS isolates were resistant to ≥3 and ≥5 antibiotics, respectively. Among the 24 nasopharyngeal cultures, 8 (33%) grew Staphylococcus aureus, and 1 of the 8 isolates (13%) was resistant to all penicillin, cephalosporin, macrolide, and fluoroquinolone antibiotics tested. Conclusions: Our results demonstrate subtantial levels of resistance to third- and fourth-generation fluoroquinolones and multiresistance among ocular CNS isolated from patients undergoing IVT injections for CNV. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01616420
- Volume :
- 117
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 55617471
- Full Text :
- https://doi.org/10.1016/j.ophtha.2010.03.034