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Menopausal Hormone Therapy and Risk of Endometrial Carcinoma Among Postmenopausal Women in the European Prospective Investigation into Cancer and Nutrition.
- Source :
-
American Journal of Epidemiology . Dec2010, Vol. 172 Issue 12, p1394-1403. 10p. 5 Charts. - Publication Year :
- 2010
-
Abstract
- Estrogen-only menopausal hormone therapy (HT) increases the risk of endometrial cancer, but less is known about the association with other types of HT. Using Cox proportional hazards regression, the authors examined the association of various types of HT with the risk of endometrial cancer among 115,474 postmenopausal women recruited into the European Prospective Investigation into Cancer and Nutrition between 1992 and 2000. After a mean follow-up period of 9 years, 601 incident cases of endometrial cancer were identified. In comparison with never users of HT, risk of endometrial cancer was increased among current users of estrogen-only HT (hazard ratio (HR) = 2.52, 95% confidence interval (CI): 1.77, 3.57), tibolone (HR = 2.96, 95% CI: 1.67, 5.26), and, to a lesser extent, estrogen-plus-progestin HT (HR = 1.41, 95% CI: 1.08, 1.83), although risks differed according to regimen and type of progestin constituent. The association of HT use with risk was stronger among women who were older, leaner, or had ever smoked cigarettes. The finding of a strong increased risk of endometrial cancer with estrogen-only HT and a weaker association with combined HT supports the hypothesis that progestins have an attenuating effect on endometrial cancer risk. The increased risk associated with tibolone use requires further investigation. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *ESTROGEN replacement therapy
*THERAPEUTIC use of progestational hormones
*AGE distribution
*ANALYSIS of variance
*CANCER
*CHI-squared test
*COMPARATIVE studies
*CONFIDENCE intervals
*STATISTICAL correlation
*REPORTING of diseases
*ENDOMETRIAL cancer
*HORMONE therapy
*LEANNESS
*LONGITUDINAL method
*QUESTIONNAIRES
*REGRESSION analysis
*SMOKING
*SECONDARY analysis
*CONTROL groups
*DISEASE incidence
*PROPORTIONAL hazards models
*POSTMENOPAUSE
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 172
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 55775986
- Full Text :
- https://doi.org/10.1093/aje/kwq300