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Correlation between overexpression of transforming growth factor-beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women
- Source :
-
International Journal of Gynecology & Obstetrics . Jan2011, Vol. 112 Issue 1, p11-14. 4p. - Publication Year :
- 2011
-
Abstract
- <bold>Objective: </bold>To compare the expression profiles of transforming growth factor-beta 1 (TGF-β1) and its receptors in occluded tubes of infertile women with those of control patients and to evaluate the potential correlation with postsurgical pregnancy outcome.<bold>Methods: </bold>The expression profiles of TGF-β1, TGF-β1R1, and TGF-β1R2 in occluded fallopian tubes were compared using immunohistochemistry between 60 infertile patients with adhered tubes and 60 control patients with normal tubes; potential correlations with postsurgical fertility were evaluated at 2-year follow up.<bold>Results: </bold>Immunostainings of TGF-β1, TGF-β1R1, and TGF-β1R2 were all significantly elevated in patients with adhered tubes compared with normal specimens (P<0.001). In adhered specimens, correlation analyses showed positive correlations between TGF-β1 and TGF-β1R1 (P=0.008), and TGF-β1 and TGF-β1R2 (P=0.035). At 2-year follow up, 32 of the 60 infertile women had achieved normal pregnancies, 5 had had ectopic pregnancies, and 23 remained infertile. Correlation analysis showed that TGF-β1 expression level was negatively correlated with pregnancy outcome (r=-0.445, P<0.001), independent of adhesion severity or patient age.<bold>Conclusion: </bold>TGF-β1 expression was independently correlated with the postsurgical pregnancy outcome among infertile women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRANSFORMING growth factors-beta
*FALLOPIAN tubes
*GENE expression
*FEMALE infertility
*HEALTH outcome assessment
*PREGNANCY complications
*IMMUNOHISTOCHEMISTRY
*TUBAL sterilization
*TISSUE adhesions
*AGE distribution
*CELL receptors
*COMPARATIVE studies
*GROWTH factors
*INFERTILITY
*LONGITUDINAL method
*RESEARCH methodology
*EVALUATION of medical care
*MEDICAL cooperation
*PREGNANCY
*RESEARCH
*TRANSFERASES
*EVALUATION research
*SEVERITY of illness index
*CASE-control method
*DISEASE complications
FALLOPIAN tube diseases
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 112
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 55807570
- Full Text :
- https://doi.org/10.1016/j.ijgo.2010.07.016