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Photodynamic Therapy with the Silicon Phthalocyanine Pc 4 Induces Apoptosis in Mycosis Fungoides and Sezary Syndrome.
- Source :
-
Advances in Hematology . 2010, Vol. 2010, p1-8. 8p. 1 Color Photograph, 4 Graphs. - Publication Year :
- 2010
-
Abstract
- Our current focus on the effects of Photodynamic Therapy (PDT) using silicon phthalocyanine Pc 4 photosensitizer on malignant T lymphocytes arose due to preclinical observations that Jurkat cells, common surrogate for human T cell lymphoma, were more sensitive to Pc 4-PDT-induced killing than epidermoid carcinoma A431 cells. Mycosis fungoides (MF) as well as Sezary syndrome (SS) are variants of cutaneous T-cell lymphoma (CTCL) in which malignant T-cells invade the epidermis. In this study, we investigated the cytotoxicity of Pc 4-PDT in peripheral blood cells obtained from patients with SS and in skin biopsies of patients with MF. Our data suggest that Pc 4-PDT preferentially induces apoptosis of CD4+CD7- malignant T-lymphocytes in the blood relative to CD11b+ monocytes and nonmalignant T-cells. In vivo Pc 4-PDT ofMF skin also photodamages the antiapoptotic protein Bcl-2. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16879104
- Volume :
- 2010
- Database :
- Academic Search Index
- Journal :
- Advances in Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 56504440
- Full Text :
- https://doi.org/10.1155/2010/896161