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Reduction of skin-homing cytotoxic T cells (CD8.
- Source :
-
Photodermatology, Photoimmunology & Photomedicine . Feb2011, Vol. 27 Issue 1, p40-44. 5p. 1 Chart, 2 Graphs. - Publication Year :
- 2011
-
Abstract
- Vitiligo is a frequently acquired, hereditary disease, characterized by achromic macules due to the absence of melanocytes. In contrast with earlier studies, in which the main pathogenic role was attributed to anti-melanocyte antibodies, recent papers have emphasized a role for CD8 cytotoxic T lymphocytes in melanocyte destruction. Fifteen percent of peripheral T cell express cutaneous lymphocyte-associated antigen (CLA), responsible for skin-homing T cell. Phototherapy is used to treat patients with generalized vitiligo and it has been shown to interfere with CLA T cells in other skin diseases. To describe peripheral blood T cell subpopulations' frequency and ability to express the skin-homing molecule (CLA) in patients with non-segmental vitiligo, before and after photochemotherapy (PUVA). Twenty-two patients with generalized and active spreading vitiligo were submitted to 30 PUVA-8MOP sessions. Lymphocyte immunophenotyping was performed by flow cytometry using anti-CD3, anti-CD8 and anti-CLA monoclonal antibodies. Fifteen healthy volunteers, sex- and age-matched, were included as a control group. CD8-CLA T cells were significantly reduced in number in untreated vitiligo patients ( P=0.008) when compared with control individuals, albeit with a more intense CLA expression ( P=0.028). These findings were not altered after PUVA. No significant difference was noticed in CD4/CD8 ratios nor in CD4-CLA T cell numbers between vitiligo patients and controls, both before and after PUVA. CD8-CLA T cells are reduced in peripheral blood of patients with non-segmental vitiligo. This finding may be related to the previously reported increase of CD8 cells in both lesions and perilesional skin of these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*VITILIGO
*PIGMENTATION disorders
*MELANOCYTES
*ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 09054383
- Volume :
- 27
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Photodermatology, Photoimmunology & Photomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 56942902
- Full Text :
- https://doi.org/10.1111/j.1600-0781.2010.00563.x