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One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor
- Source :
-
Applied Radiation & Isotopes . Feb2011, Vol. 69 Issue 2, p418-422. 5p. - Publication Year :
- 2011
-
Abstract
- Abstract: The biotin–avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine—funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09698043
- Volume :
- 69
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Applied Radiation & Isotopes
- Publication Type :
- Academic Journal
- Accession number :
- 57076614
- Full Text :
- https://doi.org/10.1016/j.apradiso.2010.10.012