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Acupuncture accelerates wound healing in burn-injured mice

Authors :
Lee, Jin-Ah
Jeong, Ha Jin
Park, Hi-Joon
Jeon, Songhee
Hong, Seung-Ug
Source :
Burns (03054179). Feb2011, Vol. 37 Issue 1, p117-125. 9p.
Publication Year :
2011

Abstract

Abstract: The effects of acupuncture on healing of deep second degree burns were compared to the conventional hydrocolloid dressing, Duoderm in mice. The expression level of inflammatory protein-1α (MIP-1α) was significantly reduced in the injured skin and the number of eosinophils in blood decreased significantly following the acupuncture treatment compared to the Duoderm dressing at 7 days after the burn. In addition, the acupuncture treatment was more effective in decreasing the wound size and inducing epidermal regeneration. Histological findings also revealed that there was less leukocyte infiltration and a greater reduction in the immunohistochemical reaction to MIP-2 in the wounds treated with acupuncture versus Duoderm. Furthermore, the numbers of BrdU- and basic fibroblast growth factor (bFGF)-positive cells were significantly increased by the acupuncture treatment, compared to the Duoderm treatment at 7 days. Moreover, in the acupuncture treated mice, the expression of fibronectin was increased and α-SMA was decreased at 7 days. Thus, this present study demonstrates that acupuncture accelerates the skin regeneration process following deep second degree burns. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03054179
Volume :
37
Issue :
1
Database :
Academic Search Index
Journal :
Burns (03054179)
Publication Type :
Academic Journal
Accession number :
57079154
Full Text :
https://doi.org/10.1016/j.burns.2010.07.005