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Synthesis, characterization and in vitro antitumor activity of three organotin(IV) complexes with carbazole ligand
- Source :
-
Inorganica Chimica Acta . Jan2011, Vol. 365 Issue 1, p302-308. 7p. - Publication Year :
- 2011
-
Abstract
- Abstract: Three novel organotin(IV) complexes with 2-(9H-carbazol-9-yl) acetic acid (HL), of the formulae {[nBu2SnOL]2O}2 (1), [nBuSn(O)OL]6 (2) and [nBu3SnOL]6 (3) were prepared. All compounds were characterized by X-ray crystallography, confirming that complex (1) is tetranuclear one with ladder framework, complex (2) is a hexanuclear organotin(IV) complex with drum structure and complex (3) is a macrocycle with 24-membered stannoxane ring. Furthermore, all complexes were tested in vitro for their cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2). Complex (1) displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00201693
- Volume :
- 365
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Inorganica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 57143887
- Full Text :
- https://doi.org/10.1016/j.ica.2010.09.024