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Unusual reactivity of acetylacetone with imidazole/histamine complexes and (M=Re, 99mTc)

Authors :
Benny, Paul D.
Fugate, Glenn A.
Ganguly, Tanushree
Twamley, Brendan
Bučar, Dejan-Krešimir
MacGillivray, Leonard R.
Source :
Inorganica Chimica Acta. Jan2011, Vol. 365 Issue 1, p356-362. 7p.
Publication Year :
2011

Abstract

Abstract: The (M=Re, 99mTc) moiety was investigated with a known bidentate ligand, acetylacetone (acac) and imidazole based ligands in a 2+1 and tridentate approach. In the 2+1 approach, the fac-Re(CO)3(acac)(OH2) was reacted with imidazole or 1-methylimidazole to yield a unique anionic μ-bridging imidazol-1-ide dimer fac-[(imidazol-1-ide)-bis-(fac-acetylacetonatotricarbonylrhenium (I)], 1, or the monomer version fac-M(CO)3(acac)(1-methylimidazole), 2, respectively. Based on the Schiff base condensation of a ketone and a primary amine, a tridentate ligand approach for utilizing the reactivity of acac and histamine was explored in a didactic manner: (1) an in situ ligand synthesis approach reacting fac-M(CO)3(acac)(OH2) with histamine (2+2=3) that led to the formation of an unexpected dimer μ-acachistimine, compound, 3, or (2) direct complexation of with the prepared ligand acachistimine, 4, to yield the monomer product fac-M(CO)3(acachistimine), 5. The results observed with rhenium complexes characterized by standard chemical analysis and X-ray analysis correlated with the radioactive experiments conducted with . [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00201693
Volume :
365
Issue :
1
Database :
Academic Search Index
Journal :
Inorganica Chimica Acta
Publication Type :
Academic Journal
Accession number :
57143894
Full Text :
https://doi.org/10.1016/j.ica.2010.09.050