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Trans-acting proteins regulating mRNA maturation, stability and translation in trypanosomatids
- Source :
-
Trends in Parasitology . Jan2011, Vol. 27 Issue 1, p23-30. 8p. - Publication Year :
- 2011
-
Abstract
- In trypanosomatids, alterations in gene expression in response to intrinsic or extrinsic signals are achieved through post-transcriptional mechanisms. In the last 20 years, research has concentrated on defining the responsible cis-elements in the untranslated regions of several regulated mRNAs. More recently, the focus has shifted towards the identification of RNA-binding proteins that act as trans-acting factors. Trypanosomatids have a large number of predicted RNA-binding proteins of which the vast majority have no orthologues in other eukaryotes. Several RNA-binding proteins have been shown to bind and/or regulate the expression of a group of mRNAs that code for functionally related proteins, indicating the possible presence of co-regulated mRNA cohorts. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14714922
- Volume :
- 27
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Trends in Parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 57164295
- Full Text :
- https://doi.org/10.1016/j.pt.2010.06.011