Back to Search
Start Over
Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome
- Source :
-
Clinica Chimica Acta . Feb2011, Vol. 412 Issue 5/6, p435-440. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: Background: Low-density lipoprotein cholesterol (LDL-C) and oxidized low-density lipoprotein (ox-LDL) are probably associated with atherosclerosis and coronary artery disease. The influence of LDL-C and ox-LDL on metabolic syndrome among healthy, postmenopausal women has not been well studied. The aim of this study was to assess the association between LDL-C, ox-LDL, and metabolic syndrome in postmenopausal women. Methods: The study design was a cross-sectional study. A total of 1309 postmenopausal women (355 with metabolic syndrome and 954 without metabolic syndrome) aged 60–79years were included. Lipid profiles, glucose, ox-LDL, adiponectin, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α concentrations were measured. Results: Plasma ox-LDL levels were higher in subjects with metabolic syndrome, when compared without metabolic syndrome subjects. A multiple linear regression analysis revealed that ox-LDL was significantly associated with high-density lipoprotein cholesterol, LDL-C, triglycerides, and adiponectin. After a multivariable adjustment, the odds ratios for the second, third, and fourth quartiles of ox-LDL in metabolic syndrome compared with the lowest quartile were 1.76 (95% confidence interval [CI], 1.15–2.70), 2.45 (95% CI, 1.58–3.79), and 3.98 (95% CI, 2.52–6.28), respectively. LDL levels were not significantly associated with metabolic syndrome. Conclusions: Ox-LDL concentration was associated with metabolic syndrome in postmenopausal women. These findings suggest that high ox-LDL levels are associated with high cardiovascular risk in postmenopausal women with metabolic syndrome. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00098981
- Volume :
- 412
- Issue :
- 5/6
- Database :
- Academic Search Index
- Journal :
- Clinica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 57300466
- Full Text :
- https://doi.org/10.1016/j.cca.2010.11.017