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Analysis of Gelatin Plasma Substitutes in Blood Based on Detection of Hydroxyproline Derivatives.
- Source :
-
Artificial Cells, Blood Substitutes & Biotechnology . Feb2011, Vol. 39 Issue 1, p19-25. 7p. 2 Charts, 5 Graphs. - Publication Year :
- 2011
-
Abstract
- The gelatin plasma substitute is often polydisperse and heterogenous, making it difficult to determine the elimination rate and half-life in the body. In this study, one method was developed based on quantitative determination of hydroxyproline derivatives. Two plasma substitutes were prepared by succinylation and genipin-crosslinking, respectively. After transfusion, the blood samples were hydrolyzed and derivatized, and then analyzed by HPLC. A two-phase exponential association equation was used for fitting the time-concentration curves. The results indicated that this method could be used for quantitative determination of gelatin in blood, and the pharmacokinetic parameters such as elimination rate and half-life. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10731199
- Volume :
- 39
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Artificial Cells, Blood Substitutes & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 57317341
- Full Text :
- https://doi.org/10.3109/10731199.2010.494582