Immune Responses to Rotavirus Infection and Vaccination and Associated Correlates of Protection.

The article presents the immune responses to natural rotavirus (RV) vaccination and RV infection in both experimental humans and animals. It states that RV-specific IgA antibodies in the gut lumen are related with protection from the immune responses to natural RV infection in humans and animals. It mentions that RV-specific maternal antibody may intervene with the efficacy of RV vaccination in young animals and infants.