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Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis.
- Source :
-
Arthritis & Rheumatism . Feb2011, Vol. 63 Issue 2, p445-454. 10p. - Publication Year :
- 2011
-
Abstract
- The article presents a study to investigate the influence of galectin 3 deficiency in a murine model of arthritis. Wild-type (WT) and galectin 3–deficient (galectin 3&sup–/–;) mice were subjected to antigen-induced arthritis (AIA), and the concentration of serum cytokines, antigen-specific antibodies and cellular IL-17 responses were examined. Galectin 3&sup–/–; mice showed a relatively greater suppression in joint inflammation and bone erosion, thereby suggesting that galectin 3 plays a pathogenic role in the development and progression of AIA.
Details
- Language :
- English
- ISSN :
- 00043591
- Volume :
- 63
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Arthritis & Rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 57656254
- Full Text :
- https://doi.org/10.1002/art.30118