Fingolimod provides long-term protection in rodent models of cerebral ischemia.

The article presents a study which tested the therapeutic effects of fingolimod (FTY720) in rodent models of cerebral ischemia. It evaluates the long-term behavioral outcome of fingolimod, and whether delayed treatment is still effective. The study utilized mouse models of middle cerebral artery occlusion and cell-culture models of neurotoxicity and inflammation. The results showed that fingolimod decreased infarct size and edema, and neuroprotection was associated with reduced inflammation.