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Antiproliferative Diterpenoids from the Leaves of Isodon rubescens.
- Source :
-
Planta Medica . Jan2011, Vol. 77 Issue 1, p169-174. 6p. - Publication Year :
- 2011
-
Abstract
- A phytochemical study of Isodon rubescens leaves led to the isolation of five new diterpenoids, isorubesins A-E (1-5), and fifteen known diterpenoids. The structures of these new compounds were elucidated by spectroscopic evidence. Most of the diterpenoids were tested for cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 human tumor cells. Some of them showed potent inhibitory activity. Compound 5 is the first reported atisane-type diterpenoid from this plant. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DITERPENES
*LAMIACEAE
*BOTANICAL chemistry
*SPECTRUM analysis
*TUMORS
*BOTANICAL specimens
*ANTINEOPLASTIC agents
*MOLECULAR structure
*FOLIAR diagnosis
*BIOLOGICAL assay
*CELL lines
*COLORIMETRY
*HIGH performance liquid chromatography
*MEDICINAL plants
*NUCLEAR magnetic resonance spectroscopy
*RESEARCH funding
*STATISTICS
*TERPENES
*TOXICITY testing
*PHYTOCHEMICALS
*DATA analysis
*QUANTITATIVE research
Subjects
Details
- Language :
- English
- ISSN :
- 00320943
- Volume :
- 77
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Planta Medica
- Publication Type :
- Periodical
- Accession number :
- 57802543
- Full Text :
- https://doi.org/10.1055/s-0030-1250165