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Phospholipase A2 Antagonists Inhibit Constitutive Retrograde Membrane Traffic to the Endoplasmic Reticulum.
- Source :
-
Traffic . Jun2000, Vol. 1 Issue 6, p504-511. 8p. - Publication Year :
- 2000
-
Abstract
- Eukaryotic cells contain a variety of cytoplasmic Ca2+-dependent and Ca2+-independent phospholipase A2s (PLA2s; EC 2.3.1.2.3). However, the physiological roles for many of these ubiquitously-expressed enzymes is unclear or not known. Recently, pharmacological studies have suggested a role for Ca2+-independent PLA2 (iPLA2) enzymes in governing intracellular membrane trafficking events in general and regulating brefeldin A (BFA)-stimulated membrane tubulation and Golgi-to-endoplasmic reticulum (ER) retrograde membrane trafficking, in particular. Here, we extend these studies to show that membrane-permeant iPLA2 antagonists potently inhibit the normal, constitutive retrograde membrane trafficking from the trans-Golgi network (TGN), Golgi complex, and the ERGIC-53-positive ER-Golgi-intermediate compartment (ERGIC), which occurs in the absence of BFA. Taken together, these results suggest that iPLA2 enzymes play a general role in regulating, or directly mediating, multiple mammalian membrane trafficking events. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13989219
- Volume :
- 1
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Traffic
- Publication Type :
- Academic Journal
- Accession number :
- 5789866
- Full Text :
- https://doi.org/10.1034/j.1600-0854.2000.010608.x