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Mortality Risk in Older Men Associated with Changes in Weight, Lean Mass, and Fat Mass.
- Source :
-
Journal of the American Geriatrics Society . Feb2011, Vol. 59 Issue 2, p233-240. 8p. 3 Charts, 2 Graphs. - Publication Year :
- 2011
-
Abstract
- To evaluate risk of all-cause mortality associated with changes in body weight, total lean mass, and total fat mass in older men. Longitudinal cohort study. Six U.S. clinical centers. Four thousand three hundred thirty-one ambulatory men aged 65 to 93 at baseline. Repeated measurements of body weight and total lean and fat mass were taken using dual-energy X-ray absorptiometry 4.6 ± 0.4 years apart. Percentage changes in these measures were categorized as gain (+5%), loss (-5%), or stable (−5% to +5%). Deaths were verified centrally according to death certificate reviews, and proportional hazard models were used to estimate the risk of mortality. After accounting for baseline lifestyle factors and medical conditions, a higher risk of mortality was found for men with weight loss (hazard rat (HR)=1.84, 95% confidence interval (CI)=1.50-2.26), total lean mass loss (HR=1.78, 95% CI=1.45-2.19), and total fat mass loss (HR=1.72, 95% CI=1.34-2.20) than for men who were stable for each body composition measure. Men with total fat mass gain had a slightly greater mortality risk (HR=1.29, 95% CI=0.99-1.67) than those who remained stable. These associations did not differ according to baseline age, obesity, or self-reported health status ( P for interactions >.10), although self-reported weight loss intent altered mortality risks with total fat mass ( P for interaction=.04) and total lean mass ( P for interaction=.09) change. Older men who lost weight, total lean mass, or total fat mass had a higher risk of mortality than men who remained stable. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OLDER men
*AT-risk older people
*MORTALITY
*HUMAN body composition
*LEAN body mass
Subjects
Details
- Language :
- English
- ISSN :
- 00028614
- Volume :
- 59
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of the American Geriatrics Society
- Publication Type :
- Academic Journal
- Accession number :
- 58058953
- Full Text :
- https://doi.org/10.1111/j.1532-5415.2010.03245.x