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Organocatalytic Enantioselective Mannich-Type Reactions of Fluorinated Keto Esters with N-Boc-Aldimines.
- Source :
-
Synlett . Feb2011, Vol. 2011 Issue 3, p420-424. 5p. - Publication Year :
- 2011
-
Abstract
- The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of α-fluoro-b-keto esters with N-Boc aldimines under mild reaction conditions afforded the corresponding β-aminated α-fluoro- β-keto esters with excellent enantioselectivities (up to 98% ee). [ABSTRACT FROM AUTHOR]
- Subjects :
- *MANNICH reaction
*CHIRAL drugs
*ESTERS
*ENANTIOSELECTIVE catalysis
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 09365214
- Volume :
- 2011
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Synlett
- Publication Type :
- Academic Journal
- Accession number :
- 58656895
- Full Text :
- https://doi.org/10.1055/s-0030-1259319