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A pharmacokinetic study of amoxycillin in febrile beagle dogs following repeated administrations of endotoxin.
- Source :
-
Journal of Veterinary Pharmacology & Therapeutics . Dec2001, Vol. 24 Issue 6, p379-383. 5p. 1 Chart, 5 Graphs. - Publication Year :
- 2001
-
Abstract
- The pharmacokinetics of amoxycillin was studied in nine male beagle dogs under healthy and febrile conditions. In Period 1, dogs received 20 mg/kg of an oral suspension of amoxycillin. Intravenous doses of saline, 2 and 20 μg/kg of endotoxin (LPS from Escherichia coli serotype) were administered to dogs (three per group) prior to administration of 20 mg/kg of amoxycillin in Period 2. Rectal temperature and behavioral changes were recorded and blood samples were collected over 12 h for pharmacokinetic analysis. Amoxycillin was assessed in plasma using liquid chromatography coupled with mass spectrometry. Plasma concentrations were analysed using a one-compartment model with lag-time for absorption using an iterative two-stage method. As compared with control groups, amoxycillin clearance decreased significantly with preliminary treatments of 2 μg/kg endotoxin (0.209 vs. 0.140 L/h kg, P < 0.05) and 20 μg/kg endotoxin (0.214 vs. 0.075 L/h kg, P < 0.05). As a result of this, the area under curve for the 2 and 20 μg/kg endotoxin groups increased significantly 100.4 vs. 149.4 μg h/mL (P < 0.05) and 99.2 vs. 277.7 μg h/mL (P < 0.05), respectively. Other drugs currently used for the treatment of fever and septic shock should be re-evaluated using a febrile animal model to avoid improper dose administration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHARMACOKINETICS
*ENDOTOXINS
*LIQUID chromatography
Subjects
Details
- Language :
- English
- ISSN :
- 01407783
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Veterinary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 5884659
- Full Text :
- https://doi.org/10.1046/j.1365-2885.2001.00359.x