FMD subunit vaccine produced using a silkworm–baculovirus expression system: Protective efficacy against two type Asia1 isolates in cattle

Abstract: Cattle vaccinated with a single dose of subunit vaccine containing the capsid and 3C proteinase coding regions of foot-and-mouth disease virus (FMDV) Asia I/HNK/CHA/05 strain were protected when challenged 28 days later with a homologous virus. Here, the 50% bovine protective dose (PD50) test was performed to assess the potency of the subunit vaccine. When challenged with two Chinese isolates, the subunit vaccine could achieve 6.5PD50 (challenged with Asia I/HNK/CHA/05 strain) and 5.2PD50 (challenged with Asia I/JSL/05 strain) per dose. [Copyright &y& Elsevier]