Combined Oral and Intranasal Corticosteroid Therapy: An Advance in the Management of Nasal Polyposis?

The authors reflect on the efficiency of combined oral and intranasal corticosteroid therapy in nasal polyposis management. They note that corticosteroids exert anti-inflammatory effect by acting on particular receptors in human cells. They mention studies demonstrating that patients with nasal polyps who are sensitive to aspirin are susceptible to resist steroid treatment without glucocorticoid receptors' downregulation.