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The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs.
- Source :
-
Inhalation Toxicology . Mar2011, Vol. 23 Issue 3, p157-165. 9p. - Publication Year :
- 2011
-
Abstract
- Pulmonary complications of sulfur mustard (SM) range from mild respiratory symptoms to even severe bronchial stenosis. In the present study, the protective effect of vitamin E on tracheal responsiveness (TR) and lung inflammation of SM-exposed guinea pigs were examined. Guinea pigs were exposed to ethanol (control group), 40 mg/m3 inhaled SM and ethanol vehicle (sulfur mustard exposed (SME) group), SME treated with vitamin E (SME ++ E), SME with dexamethasone (SME ++ D) and both drugs (SME ++ E ++ D), ( n == 8 for each group). TR to methacholine, total and differential white blood cell (WBC) count of lung lavage and serum cytokines were evaluated 14 days post-exposure. TR, WBC, interleukin 4 (IL-4), interferon gamma (INF-γγ), eosinophil, and monocyte levels in SME guinea pigs were significantly higher, but lymphocyte was lower than those of controls ( P < 0.05 to P < 0.001). TR, IL-4, and eosinophil levels in SME ++ E, SME ++ D and SME ++ E ++ D, INF-γγ in SME ++ E and SME ++ E ++ D and WBC in SME ++ E were significantly decreased compared to that of the SME group ( P < 0.01 to P < 0.001). In addition, the TR of SME ++ D ++ E was significantly higher than that of SME ++ E ( P < 0.01) and SME ++ D ( P < 0.05) groups. The results showed a preventive effect of vitamin E, dexamethasone and their combination on TR and lung inflammation in SME guinea pigs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08958378
- Volume :
- 23
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Inhalation Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 59224816
- Full Text :
- https://doi.org/10.3109/08958378.2011.558934