Back to Search
Start Over
The effects of Boehmeria nivea (L.) Gaud. on embryonic development: In vivo and in vitro studies
- Source :
-
Journal of Ethnopharmacology . Mar2011, Vol. 134 Issue 2, p393-398. 6p. - Publication Year :
- 2011
-
Abstract
- Abstract: Aim of the study: Boehmeria nivea (L.) Gaud. was commonly used to treat miscarriages clinically. The aim of this study was to examine its safety for embryonic development. Materials and methods: Pregnant mice were randomly assigned into 5 groups, i.e. mice were oral-treated with distilled water (G1), with Boehmeria nivea extract of 2, 8 or 32g/kg/day (G2, G3 or G4), and with 3 doses of vitamin A of 200,000IU/kg as positive controls (G5). Meanwhile, IC50 values for both embryonic stem cells (ESCs) and 3T3 cells were detected by cytotoxicity assays. Results: (1) The resorptions and malformed fetuses in G5 were significantly higher than G1 (P <0.001), whereas the maternal body-weight and uterus-weight were lower than G1 (P <0.05); (2) there was no difference in the fetal body-weight, maternal relative body-weight gain, liver-, kidney- or heart-weight, relative organ-weight, and histological examination among five groups; (3) there was no difference in IC50 values between ESCs and 3T3 cells, but high concentration of Boehmeria nivea extract might significantly lower ESCs’ viability (P <0.05). Conclusion: Boehmeria nivea extract at 32g/kg/day did not cause significant embryotoxicity or maternal toxicity in mice, although it might cause cytotoxicity in cultured ESCs at a high dose. [Copyright &y& Elsevier]
- Subjects :
- *ANALYSIS of variance
*ANIMAL experimentation
*ANTHROPOMETRY
*BIOLOGICAL assay
*BIOPHYSICS
*CHI-squared test
*COMPUTER software
*DOSE-effect relationship in pharmacology
*DRUG toxicity
*HISTOLOGICAL techniques
*MATHEMATICS
*RESEARCH methodology
*MEDICINAL plants
*MICE
*MISCARRIAGE
*RESEARCH funding
*STATISTICAL sampling
*STATISTICS
*T-test (Statistics)
*VITAMIN A
*PLANT extracts
*DATA analysis
*EMBRYOS
*STATISTICAL significance
*FETAL development
Subjects
Details
- Language :
- English
- ISSN :
- 03788741
- Volume :
- 134
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 59326585
- Full Text :
- https://doi.org/10.1016/j.jep.2010.12.034