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Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates.

Authors :
Jing Nie
Hong-Chao Guo
Dominique Cahard
Jun-An Ma
Source :
Chemical Reviews. Feb2011, Vol. 111 Issue 2, p455-529. 75p. 132 Diagrams, 107 Charts.
Publication Year :
2011

Abstract

The article talks about enantiopure trifluoromethylated molecules. Fluorine has been one of the elements that played a critical role in the pharmaceutical and material sciences. The addition of one or two flourine atoms has been a familiar technique in every new drug discovery and one of the leading fluorine compounds that has been recently discovered is the enantiopure trifluoromethylated molecule which is often included in biologically active compounds, chiral reagents, and in materials for optoelectronic devices.

Details

Language :
English
ISSN :
00092665
Volume :
111
Issue :
2
Database :
Academic Search Index
Journal :
Chemical Reviews
Publication Type :
Academic Journal
Accession number :
59576355
Full Text :
https://doi.org/10.1021/cr100166a