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Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation.
- Source :
-
Clinical Transplantation . Mar/Apr2011, Vol. 25 Issue 2, p297-301. 5p. 1 Chart, 1 Graph. - Publication Year :
- 2011
-
Abstract
- Levesque E, Hoti E, Azoulay D, Adam R, Samuel D, Castaing D, Saliba F. Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation. Clin Transplant 2011: 25: 297-301. © 2010 John Wiley & Sons A/S. The clinical presentation of hepatic artery thrombosis (HAT) post-liver transplantation (LT) varies considerably. Doppler ultrasonography (Doppler US) is the first line investigation, with a diagnostic sensitivity for HAT as high as 92%. Because indocyanine green (ICG) elimination from the blood depends among other factors on the hepatic blood flow, we hypothesized that plasma disappearance rate of indocyanine green (PDR-ICG) can be influenced by the flow in the hepatic artery. Thus, we evaluated the role of PDR-ICG measurement in HAT diagnosis in post-LT patients. Fourteen liver transplant patients with no visible flow in the hepatic artery (Doppler US) were identified. Of the 14, seven patients had HAT confirmed by CT-angiography. The PDR-ICG measurement, an investigation routinely used in our center, was performed in all 14 patients. The PDR-ICG in patients with HAT was significantly lower than in patients without HAT (5.8 ± 4.3 vs. 23.8 ± 7.4%/min, p = 0.0009). In patients with HAT, after the revascularization, the PDR-ICG value increased (5.8 ± 4.3 vs. 15.6 ± 3.5%/min, p = 0.006). The ICG elimination may be an adjunct diagnostic tool in the management of patients with suspected HAT following LT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09020063
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Clinical Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 59748751
- Full Text :
- https://doi.org/10.1111/j.1399-0012.2010.01252.x