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N 5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Apr2011, Vol. 21 Issue 8, p2351-2353. 3p. - Publication Year :
- 2011
-
Abstract
- Abstract: A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N 5-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 21
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 59773360
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.02.081