Back to Search
Start Over
Pharmacokinetics and bioavailability of valnemulin in broiler chickens.
- Source :
-
Journal of Veterinary Pharmacology & Therapeutics . Jun2011, Vol. 34 Issue 3, p247-251. 5p. 1 Chart, 2 Graphs. - Publication Year :
- 2011
-
Abstract
- Wang, R., Yuan, L.G., He, L.M., Zhu, L.X., Luo, X.Y., Zhang, C.Y., Yu, J.J., Fang, B.H., Liu, Y.H. Pharmacokinetics and bioavailability of valnemulin in broiler chickens. J. vet. Pharmacol. Therap., 247-251. The objective of this study was to investigate the pharmacokinetics and bioavailability of valnemulin in broiler chickens after intravenous (i.v.), intramuscular (i.m.) and oral administrations of 10 mg/kg body weight (bw). Plasma samples were analyzed by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Pharmacokinetic characterization was performed by non-compartmental analysis using WinNonlin program. After intravenous administration, distribution was wide with the volume of distribution based on terminal phase(V) of 4.27 ± 0.99 L /kg. Mean valnemulin t(h), Cl(L /h /kg), V (L /kg) and AUC(μg·h /mL) values were 2.85, 0.99, 2.72 and 10.34, respectively. After intramuscular administration, valnemulin was rapidly absorbed with a C of 2.2 μg/mL achieved at 0.43 h (t), and the absolute bioavailability (F) was 88.81%; and for the oral route the same parameters were 0.66 ± 0.15 μg/mL, 1.54 ± 0.27 h and 74.42%. A multiple-peak phenomenon was present after oral administration. The plasma profile of valnemulin exhibited a secondary peak during 2-6 h and a tertiary peak at 32 h. The favorable PK behavior, such as the wide distribution, slow elimination and acceptable bioavailability indicated that it is likely to be effective in chickens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01407783
- Volume :
- 34
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Veterinary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 59989055
- Full Text :
- https://doi.org/10.1111/j.1365-2885.2010.01215.x