Regioselective Preparation of Functionalized Isoxazoline Derivatives as Key Intermediates for the Synthesis of Selective N-Methyl-D-aspartate Receptor Antagonists.

Two highly versatile isoxazoline derivatives, as key intermediates for the synthesis of differently functionalized subtypeselective N-methyl-D-aspartate receptor antagonists, were designed and synthesized. The synthetic strategy is based on an intramolecular nitrile oxide cycloaddition reaction which is a powerful method capable of controlling both the regio- and stereochemistry of the pericyclic reaction. [ABSTRACT FROM AUTHOR]